The first experience of cord blood stem cells application in kidney transplantation: A descriptive study

Abstract. Kidney transplantation is recognized as the optimal method of end-stage kidney disease treatment, but chronic renal allograft rejection remains an unresolved issue and leads to transplanted organ function loss. Recent studies show positive effects stem cell injections in a variety diseases, including transplantation.
 The present study aimed analyze first experience umbilical cord blood cells application living-related Shalimov’s National Institute Surgery Transplantation, give preliminary assessment their effectiveness safety, evaluate clinical course especially dynamics laboratory parameters recipient’s postoperative period.
 Methods. group included 6 male, adult recipients transplants, who performed allotransplantation from living family donor Transplantology 2020 – 2021. Before surgery, all patients received intravenous administration fraction nuclear human at dose 2-3 x 106/kg body weight combination with standard three-component immunosuppressive therapy. Immune system were before transplantation, on third days period, end second week, well first, third, sixth, twelfth months, following transplantation. Renal graft was assessed by serum creatinine glomerular filtration rate. Monitoring urine, concentration calcineurin inhibitors (C0) carried out regularly three times week for month, twice month once until year.
 Puncture biopsy months after surgery diagnose pathology graft, namely manifestations acute rejection, nature degree which determined according Banff classification.
 state immune characterized indicators cellular humoral immunity.
 Statistical processing research results using statistical package StatSoft (2010) STATISTICA 9.1 Windows Inc, Tusla.
 Results. All without complications. On day average diuresis 9415 ± 928.1 ml. Normalization observed or (GFR more than 90 ml/ min/1.73 m2). There no rejections grafts signs opportunistic infections during 1 year follow-up period. Morphological did not reveal significant pathological changes kidneys induction therapy.
 dynamics, given insufficient number patients, requires further research.
 Conclusions. prior safe promotes rapid recovery function. morphological proven allows us predict its long-term functioning future. To assess response recipient's accumulation additional data.